Mali is the top country by malaria cases in the world. As of 2015, malaria cases in Mali was 448.6 per 1,000 population at risk that accounts for 5.17 % of the world's malaria cases. The top 5 countries (others are Burkina Faso, Nigeria, Guinea, and Niger) account for 22.40 % of it. The world's total malaria cases was estimated at 8,672.11 per 1,000 population at risk in 2015.
Malaria incidence is expressed as the number of new cases of malaria per 100,000 people each year. The number of cases reported is adjusted to take into account incompleteness in reporting systems, patients seeking treatment in the private sector, self-medicating or not seeking treatment at all, and potential over-diagnosis through the lack of laboratory confirmation of cases.